An End to Dieting for People with Type 2 Diabetes?


For people with type 2 (adult-onset) diabetes, the prescription is typically “lose weight.” But maybe not for much longer.

University of Virginia School of Medicine researcher Daniel Cox has received $2.7 million from the National Institutes of Health to test an alternative strategy that could let people with diabetes eat as much as they want. Cox, of the Department of Psychiatry and Neurobehavioral Sciences, developed the approach after being diagnosed with type 2 diabetes, in which the body produces insulin, but can’t use it properly.

“I knew myself,” he said. “I’d been trying to lose weight forever, and that wasn’t going to happen.”

When UVA researcher Daniel Cox was diagnoses with type 2 diabetes, he knew losing weight was not going to be a likely option for himself. So he sought another approach. (UVA Health System photo)

His new, tri-pronged approach aims to use blood glucose monitoring to “educate, activate and motivate.” The underlying principle is that making people more aware of changes in their glucose levels may encourage them to avoid foods that spike their blood sugar and help them appreciate the benefits of physical activity. With that information, he hopes, they will be better equipped to manage their diabetes – possibly without the need to lose weight or even take medication.

“We’re not trying to change your behavior,” he said. “We are trying to give you choices. It’s up to you.”

Cox has tested his approach previously using finger-stick blood monitoring, but now he’s adding a new, high-tech dimension: continuous glucose monitoring, performed by an electronic sensor that reports blood sugar levels to a smartphone app in real time. Participants equipped with the sensor will be able to see, right away, how a carbohydrate-rich meal spikes their blood sugar and how physical activity can bring it back down.

The researchers will follow that up with a much larger study of 200 people examining the effectiveness of three variations of his program. One uses no monitoring, one uses conventional blood testing and the third uses continuous glucose monitoring.

“If it turns out to be better [than existing treatments], this new option, this paradigm shift, should be the first choice,” Cox said. “And if it’s only equal to the existing options, that would give patients a much-needed alternative.”

All participants in the initial trial will need to make three visits to UVA over six months. There will also be three required educational programs at UVA, but those can be done by phone or internet, he said. Participants will receive free testing supplies, free medical tests, a Fitbit and $100 upon completion of the study.

The smaller study (IRB #19313) is being funded through a $200,000 grant from DexCom, the glucose monitor manufacturer. The larger study (HSR No. 19370) has received $2.7 million in support from the National Institutes of Health, grant 1R01DK108957.

Source : University of Virginia